TABLE 2.
Histomorphometry of 16-week-old control (WT) or D/D tibiae with intermittent PTH or vehicle for 4 weeks
Values are mean ± S.E. with n = 7–9 mice for each group. BFR, bone formation rate; BS, bone surface; MS, mineralizing surface; MAR, mineral apposition rate; Ob.S, osteoblast surface; N.Ob/B.Pm, number of osteoblasts per bone perimeter; O.Th, osteoid thickness; OS, osteoid surface; Os.S, osteoclast surface; N.Oc/B.Pm, number of osteoclasts per bone perimeter.
| Parameters | WT |
D/D |
||
|---|---|---|---|---|
| PBS (n = 8) | PTH (n = 8) | PBS (n = 7) | PTH (n = 9) | |
| BV/TV (%) | 4.84 ± 0.80 | 5.97 ± 1.04 | 3.72 ± 0.54 | 5.10 ± 0.91 |
| Tb.Th (μm) | 33.62 ± 3.28 | 35.57 ± 2.34 | 28.73 ± 1.63 | 32.42 ± 1.80 |
| Tb.N (/mm) | 1.44 ± 0.19 | 1.61 ± 0.24 | 1.27 ± 0.15 | 1.54 ± 0.23 |
| Tb.Sp (μm) | 759 ± 109 | 708 ± 133 | 823 ± 94 | 839 ± 228 |
| MS/BS (%) | 21.27 ± 1.43 | 31.54 ± 1.66a | 24.97 ± 1.28 | 25.70 ± 2.24 |
| MAR (μm/day) | 1.90 ± 0.14 | 2.34 ± 0.12a | 1.56 ± 0.21 | 2.52 ± 0.13a |
| BFR/BS (μm3/μm2/year) | 147 ± 14 | 270 ± 23a | 141 ± 20 | 238 ± 26a |
| Ob.S/BS (%) | 14.25 ± 2.77 | 29.45 ± 2.15a | 17.97 ± 3.59 | 31.47 ± 2.77a |
| N.Ob/B.Pm (/mm) | 11.47 ± 1.95 | 23.64 ± 1.75a | 14.09 ± 3.05 | 22.87 ± 1.67a |
| OS/BS (%) | 4.36 ± 1.12 | 19.51 ± 1.86a | 7.45 ± 2.35 | 14.41 ± 1.51a |
| O.Th (μm) | 2.31 ± 0.30 | 2.83 ± 0.18 | 2.48 ± 0.12 | 2.73 ± 0.15 |
| Oc.S/BS (%) | 2.36 ± 0.69 | 5.24 ± 0.97a | 3.39 ± 0.64 | 5.82 ± 1.04 |
| N.Oc/B.Pm (/mm) | 0.94 ± 0.28 | 1.97 ± 0.36a | 1.37 ± 0.29 | 2.55 ± 0.61 |
a p < 0.05 versus respective PBS control.