FIGURE 4.

Numerical solutions of the extended CLM accounting for off-pathway aggregation. Equation 10 was solved as described in Simulation 1 using k_b = 10⁻¹ (left) and k_b = 10⁻⁷ (right) and the values of k_off given in the color bar on the right. Results are expressed as the variation with the normalized time k_at of the predicted amyloid fluorescence signal F/F_a (equivalent to α_a) (a and b), the amyloid conversion a (c and d), the modified amyloid conversion α/(1 − α) in log-linear scale (e and f), and the dimensionless amount of total aggregates m/M₀ (g and h).