Table 3.
Adverse event, n (%) | Lurasidone 20 mg/day(n = 71) | Lurasidone 40 mg/day(n = 67) | Lurasidone 80 mg/day(n = 71) | Haloperidol 10 mg/day(n = 72) | Placebo (n = 72) |
---|---|---|---|---|---|
At least one adverse event | 53 (74.6) | 57 (85.1) | 56 (78.9) | 63 (87.5) | 57 (79.2) |
Headache | 16 (22.5) | 15 (22.4) | 16 (22.5) | 14 (19.4) | 23 (31.9) |
Sedation | 7 (9.9) | 11 (16.4) | 14 (19.7) | 14 (19.4) | 6 (8.3) |
Dyspepsia | 10 (14.1) | 8 (11.9) | 10 (14.1) | 7 (9.7) | 9 (12.5) |
Nausea | 8 (11.3) | 7 (10.4) | 13 (18.3) | 4 (5.6) | 8 (11.1) |
Akathisia | 4 (5.6) | 9 (13.4) | 13 (18.3) | 14 (19.4) | 7 (9.7) |
Vomiting | 5 (7.0) | 5 (7.5) | 12 (16.9) | 4 (5.6) | 5 (6.9) |
Somnolence | 4 (5.6) | 4 (6.0) | 8 (11.3) | 9 (12.5) | 4 (5.6) |
Fatigue | 5 (7.0) | 2 (3.0) | 9 (12.7) | 6 (8.3) | 3 (4.2) |
Agitation | 6 (8.5) | 7 (10.4) | 2 (2.8) | 2 (2.8) | 3 (4.2) |
Insomnia | 5 (7.0) | 5 (7.5) | 4 (5.6) | 10 (13.9) | 4 (5.6) |
Extrapyramidal disorder | 2 (2.8) | 4 (6.0) | 4 (5.6) | 15 (20.8) | 3 (4.2) |
Constipation | 2 (2.8) | 1 (1.5) | 6 (8.5) | 3 (4.2) | 9 (12.5) |
Dystonia | 0 (0) | 2 (3.0) | 2 (2.8) | 11 (15.3) | 1 (1.4) |