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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Curr Opin Rheumatol. 2016 Jan;28(1):83–88. doi: 10.1097/BOR.0000000000000237

Figure 1. Relationships between the SSc molecular networks in skin.

Figure 1

Shown is a summary of core, conserved molecular processes in SSc skin. This includes an inflammatory subnetwork that contains both interferon and M2 macrophage modules that interact via Ras-Rac signaling. ECM module appears to represent a transition state between inflammatory and fibroproliferative subnetworks and is connected to M2 macrophages via chemokine signaling and to proliferation module via TGF-β signaling. The proliferation module is connected to the M2 macrophage module via fatty acid signaling and to the interferon module via negative regulation by ERK/MAPK pathway. Adapted with permission from Figure 7 in [3*]. ERK – extracellular-signal-regulated kinases, MAPK – mitogen-activated protein kinases.