Fig. 3.

Comparative analysis of functional enriched pathways between necrotizing enterocolitis and Crohn’s disease. a The negative logarithm of p-values (Fisher’s test), calculated by IPA, for each of the functional categories over-represented in NEC samples was plotted against those modulated in Crohn’s disease according to published data [23–25]. Canonical pathways represented by colored squares indicating the top 12 functional pathways identified in NEC are listed in Fig. 1. As shown, 11 of them are shared between NEC and CD. Insert: Venn diagram showing the 131 canonical pathways between NEC and CD. Of the 70 pathways found in NEC, 44 were also found in CD. Thresholds (dotted lines) denote the limit of statistical significance (p = 0.05 [-Log (0.05) =1.3]). b Venn diagram showing ToppCluster enrichment analysis associated with NEC patients and adult CD using phenotype terms. c Heatmap of some common genes found in the intersection of the ToppCluster enrichment analysis between NEC and adult CD as detailed in Additional file 6: Table S6