Fig. 4.

Comparative analysis of functional enriched pathways between necrotizing enterocolitis and pediatric Crohn’s disease. a The negative logarithm of p-values (Fisher’s test), calculated by IPA, for each of the functional categories over-represented in NEC samples was plotted against those modulated in pedCD according to published data. [26] Canonical pathways represented by colored squares indicate the top 12 functional pathways identified in NEC as listed in Fig. 1. As shown, 9 of them are shared between NEC and CD. Insert: Venn diagram showing the 153 canonical pathways identified in NEC and pedCD. Of the 70 pathways found in NEC, 47 were also found in pedCD. Thresholds (dotted lines) denote the limit of statistical significance (p = 0.05 [-Log (0.05) =1.3]). b Venn diagram showing ToppCluster enrichment analysis associated with NEC patients and pedCD using phenotype terms. c Heatmap of some common genes found in the intersection of the ToppCluster enrichment analysis between NEC and pedCD as detailed in Additional file 8: Table S8