Table 2.
Risks of first drug prescription according to first level of Anatomical Therapeutic Chemical (ATC) Classification after date of diagnosis in CD subjects compared to matched referencesa
| ATC codes | Drug category | REFERENCES (n = 5366) | CD (n = 1215) | HR (95 % CI) | ||
|---|---|---|---|---|---|---|
| n | py | n | py | |||
| A | Alimentary tract and metabolism | 537 | 38094 | 298 | 8054 | 2.55 (2.19–2.97) |
| B | Blood and blood forming organs | 258 | 40354 | 193 | 8846 | 3.69 (3.02–4.50) |
| C | Cardiovascular system | 102 | 40676 | 43 | 9511 | 1.77 (1.22–2.57) |
| D | Dermatologicals | 180 | 40060 | 55 | 9381 | 1.22 (0.88–1.69) |
| G | Genito–urinary system and sex hormones | 126 | 40749 | 38 | 9629 | 1.22 (0.83–1.79) |
| H | Systemic hormonal preparations. excluding sex hormones and insulins | 778 | 37614 | 316 | 8082 | 2.06 (1.79–2.37) |
| J | Antiinfectives for systemic use | 3660 | 17612 | 885 | 3680 | 1.27 (1.17–1.39) |
| L | Antineoplastic and immunomodulating agents | 19 | 41350 | 25 | 9697 | 5.24 (2.82–9.73) |
| M | Musculo–skeletal system | 170 | 40674 | 73 | 9436 | 1.93 (1.44–2.59) |
| N | Nervous system | 156 | 40703 | 56 | 9533 | 1.53 (1.12–2.11) |
| P | Antiparasitic products. insecticides and repellents | 216 | 40259 | 90 | 9271 | 2.01 (1.56–2.60) |
| R | Respiratory system | 2059 | 27958 | 560 | 6004 | 1.33 (1.20–1.48) |
| S | Sensory organs | 147 | 39939 | 51 | 9252 | 1.42 (1.02–1.99) |
Py: person-years; CD: celiac disease; HR: Hazard Ratio; CI: confidence interval
Figures in bold are statistically significant results (p-value <0.05)
aMatched by year of birth, gender and maternal education; analysis restricted to subjects with index date ≥1995 (because drug prescription data are available from that year)