Table 3.
Risks of first hospital admission according to ICD9–CM classification after date of diagnosis in CD subjects compared to matched references, stratified by first outcome occurrence (30–365 days after the index date/>365 days after the index date)a
| First outcome occurrence | 30–365 days | >1 year after index dateb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ICD codes | REFERENCES | CD | HR (95 % CI) | REFERENCES | CD | HR (95 % CI) | ||||
| n | py | n | py | n | py | n | py | |||
| 001–V89 | 281 | 5260 | 243 | 1095 | 4.28 (3.56–5.13) | 964 | 27812 | 256 | 4820 | 1.58 (1.36–1.85) |
| 001–139 | 18 | 5380 | 17 | 1221 | 4.38 (2.25–8.55) | 55 | 35520 | 27 | 8176 | 2.23 (1.37–3.63) |
| 140–239 | 8 | 5384 | 6 | 1226 | 2.88 (0.94–8.85) | 6 | 35836 | 21 | 8459 | 1.72 (1.00–2.98) |
| 240–279 | 12 | 5383 | 24 | 1216 | 8.37 (4.12–16.99) | 84 | 35553 | 45 | 8112 | 2.42 (1.66–3.52) |
| 280–289 | 7 | 5426 | 13 | 1309 | -- | 16 | 35947 | 12 | 8392 | 2.70 (1.21–6.04) |
| 290–319 | 12 | 5476 | 9 | 1272 | -- | 48 | 35819 | 26 | 8394 | 2.26 (1.37–3.72) |
| 320–389 | 32 | 5375 | 13 | 1224 | 1.83 (0.94–3.56) | 82 | 35306 | 43 | 8190 | 2.26 (1.54–3.32) |
| 390–459 | 2 | 5388 | 0 | 1229 | -- | 27 | 36017 | 16 | 8537 | 2.99 (1.59–5.64) |
| 460–519 | 66 | 5356 | 38 | 1213 | 2.62 (1.74–3.95) | 281 | 32991 | 83 | 7550 | 1.34 (1.03–1.73) |
| 520–579 | 30 | 5375 | 123 | 1156 | 18.96 (12.52–28.70) | 190 | 34853 | 109 | 6690 | 3.07 (2.38–3.97) |
| 580–629 | 23 | 5378 | 11 | 1226 | 1.92 (0.88–4.19) | 71 | 35483 | 31 | 8307 | 1.95 (1.25–3.05) |
| 630–679 | 1 | 5388 | 0 | 1229 | -- | 45 | 36006 | 15 | 8578 | 1.57 (0.87–2.82) |
| 680–709 | 6 | 5385 | 2 | 1228 | 0.81 (0.10–6.70) | 49 | 35830 | 14 | 8493 | 1.27 (0.69–2.32) |
| 710–739 | 12 | 5384 | 7 | 1226 | 2.32 (0.87–6.21) | 92 | 35672 | 20 | 8490 | 0.70 (0.39–1.23) |
| 740–779 | 21 | 5381 | 16 | 1220 | 3.39 (1.74–6.59) | 69 | 35521 | 28 | 8262 | 1.80 (1.14–2.85) |
| 780–799 | 16 | 5381 | 18 | 1220 | 5.43 (2.76–10.66) | 67 | 35517 | 37 | 8193 | 2.33 (1.52–3.56) |
| 800–999 | 1 | 5389 | 1 | 1229 | 5.00 (0.31–79.95) | 166 | 36102 | 56 | 8611 | 1.33 (0.97–1.83) |
| V01–V89 | 15 | 5379 | 15 | 1223 | 4.18 (2.00–8.74) | 43 | 35713 | 26 | 8245 | 2.50 (1.50–4.17) |
Py person–years, CD celiac disease, HR Hazard Ratio, CI confidence interval, Figures in bold are statistically significant results (p-value <0.05)
aMatched by year of birth, gender and maternal education; bexcluding subjects with less than one year of follow-up for each outcome