Table 4.

Risks of first drug prescription according to first level of Anatomical Therapeutic Chemical (ATC) Classification after date of diagnosis in CD subjects compared to matched references, stratified by first outcome occurrence (30–365 days after the index date/>365 days after the index date)^a

First outcome occurrence	30–365 days					>1 year after index dateb
ATC codesb	REFERENCES		CD		HR (95 % CI)	REFERENCES		CD		HR (95 % CI)
	n	py	n	py		n	py	n	py
A	131	5320	140	1129	4.70 (3.66–6.04)	406	32774	158	6926	1.78 (1.45–2.17)
B	48	5543	91	1534	6.35 (2.93–13.75)	210	34991	102	7669	2.36 (1.83–3.04)
C	18	5380	14	1222	3.53 (1.71–7.29)	84	35296	29	8289	1.42 (0.91–2.21)
D	43	5367	17	1220	1.45 (0.79–2.64)	137	34694	38	8162	1.14 (0.77–1.68)
G	22	5375	14	1221	2.38 (1.16–4.88)	104	35374	24	8408	0.97 (0.61–1.54)
H	209	5286	133	1157	3.07 (2.45–3.85)	569	32328	183	6925	1.65 (1.38–1.97)
J	1986	4300	524	941	1.27 (1.15–1.41)	1674	13312	361	2739	1.28 (1.10–1.49)
L	4	5386	12	1221	12.46 (3.94–39.42)	15	35964	13	8476	3.33 (1.52–7.29)
M	15	5383	14	1221	3.64 (1.66–7.97)	155	35291	59	8214	1.75 (1.27–2.41)
N	31	5368	16	1217	2.22 (1.20–4.12)	125	35335	40	8316	1.35 (0.93–1.97)
P	44	5368	30	1211	3.05 (1.88–4.94)	172	34891	60	8060	1.73 (1.27–2.35)
R	808	4969	248	1097	1.42 (1.23–1.65)	1251	22989	312	4907	1.26 (1.09–1.45)
S	43	5368	25	1217	2.29 (1.37–3.83)	104	34572	26	8035	1.03 (0.65–1.64)

Py: person–years; CD: celiac disease; HR: Hazard Ratio; CI: confidence interval

Figures in bold are statistically significant results (p-value <0.05)

^aMatched by year of birth, gender and maternal education; analysis restricted to subjects with index date ≥1995 (because drug prescription data are available from that year); ^bexcluding subjects with less than one year of follow-up for each outcome