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. 2016 Jan 21;9:5. doi: 10.1186/s12920-016-0164-y

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© Dumitriu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — TopGO enrichment analysis results for the proteomics study. Functional enrichment analysis was performed for 4 subsets of the significant results obtained in the MS3 proteomics study (top 25, 50, 100, all 283 genes with multiple comparison corrected significance). The top 15 enriched GO terms belonging to GO Biological Processes (BP), GO Cellular Components (CC), and GO Molecular Functions (MF) are displayed in panels a, b, and c, respectively. The presented top results are those with the smallest p-values in any of the subsets of genes used. The top category for each process implicates mitochondrial function as impaired in PD. DE = differentially expressed