Table 4.

Effect of study intervention on cognitive testing after 12 months compared to baseline

Testa	Cognitive Domain	Study Group	Percent Change (12 mon – Baseline)/(Group Baseline Average)b	P-value	Group x Time Interaction
					P-value
AVLT_LA_T1	Memory (auditory)	Control	1.8	0.726
		Nocturnal	13.8	0.307	0.743
		Transplant	−1.5	0.965
AVLT_LA_T5	Memory (auditory) & Learning	Control	9.5	0.081
		Nocturnal	14.8	0.048*	0.332
		Transplant	20.9	0.003*
AVLT Learning Score	Memory (auditory) & Learning	Control	14.9	0.213
		Nocturnal	9.9	0.681	0.609
		Transplant	35.9	0.009*
AVLT_LA_IR	Immediate Recall Memory (auditory)	Control	16.2	0.151
		Nocturnal	3.2	0.864	0.264
		Transplant	31.9	0.002*
AVLT_LA_DR	Delayed Recall Memory (auditory)	Control	−0.6	0.825
		Nocturnal	−5.4	0.242	0.021*
		Transplant	23.3	0.012*
BVMT_T1	Memory (visual-motor)	Control	−10.0	0.191
		Nocturnal	−11.7	0.203	0.619
		Transplant	5.6	0.565
BVMT_T3	Memory (visual-motor) & Learning	Control	−4.7	0.341
		Nocturnal	−9.2	0.221	0.215
		Transplant	0.9	0.933
BVMT Learning Score	Memory (visual-motor) & Learning	Control	8.8	0.76
		Nocturnal	−2.3	0.82	0.302
		Transplant	−2.2	0.558
BVMT_DR	Delayed Recall Memory (visual-motor)	Control	6.1	0.439
		Nocturnal	−18.5	0.043*	0.164
		Transplant	−3.6	0.500
Letter Number Sequence	Working Memory	Control	5.2	0.594
		Nocturnal	−0.9	0.982	0.277
		Transplant	10.2	0.082
N-Back	Working Memory, Attention (Executive function)	Control	−2.3	0.093
		Nocturnal	14.0	0.544	0.854
		Transplant	18.0	0.995
Digit Symbol	Psychomotor processing speed, (Executive Function)	Control	13.4	0.000*
		Nocturnal	3.7	0.305	0.682
		Transplant	12.2	0.054*
Chooser (Choice Reaction Time)	Psychomotor processing speed	Control	2.0	0.070
		Nocturnal	−0.6	0.752	0.591
		Transplant	10.1	0.586
Buttons (Motor Tracking)	Psychomotor processing speed	Control	−0.0	0.369
		Nocturnal	−1.2	0.946	0.558
		Transplant	−7.4	0.275
Trails A	Psychomotor Processing Speed & attention	Control	4.8	0.649
		Nocturnal	−0.2	0.907	0.660
		Transplant	−5.1	0.934
Trails B	Executive Function	Control	−4.5	0.867
		Nocturnal	−20.9	0.187	0.156
		Transplant	−3.0	0.311
Verbal Fluency (COWAT)	Language & Executive Function	Control	−23.8	0.001*
		Nocturnal	−14.6	0.080	0.017*
		Transplant	3.7	0.929

^aSee Table 1 for details on cognitive tests. * P<0.05. AVLT_LA_T1, Auditory Verbal Learning Test, word list A, first administration; AVLT_LA_T5, Auditory Verbal Learning Test, word list A, fifth administration; AVLT Learning Score, represents the difference in the maximum number of words recalled on the 4^th or 5^th administration minus the baseline recall; AVLT_LA_IR, Auditory Verbal Learning Test, word list A, immediate recall; represents immediate recall from word list A after completion of the distractor list of 15 different words; AVLT_LA_DR, Auditory Verbal Learning Test, word list A, delayed recall; represents delayed recall from word list A, 30 min after completion of the distractor list of 15 different words; BVMT_T1, Brief Visuospatial Memory Test, first administration; BVMT_T3, Brief Visuospatial Memory Test, third administration; BVMT Learning Score, measures the mean difference in the maximum and baseline performance on the BVMT at that study visit; BVMT_DR, Brief Visuospatial Memory Test, delayed recall, measures recall of the original figures following a 25-min delay

^bPercent change was computed as the difference between the twelve month visit and baseline visit divided by the average baseline score for the intervention group