(A) WIP1 expression, based on gene expression profiling, in 64 pediatric medulloblastomas, with or without gain of chromosome 17q. Copy number status of chromosome 17q was determined using an Agilent-014850 Whole Human Genome Microarray 4×44K G4112F and array-based comparative genomic hybridization (CGH). (B) WIP1 expression among medulloblastoma subgroups. Subgroup affiliation was determined using unsupervised clustering approaches. (C) WIP1 expression, segregated by Chang M stage. R2 software was used to compare WIP1 expression according to 17q status, subgroup, and M stage. (D, E) Kaplan-Meier analysis of patient survival was based on median WIP1 expression. Survival was measured from diagnosis until death or last follow-up. Patient survival was analyzed according to the Kaplan-Meier method, using log-rank statistics. The median value, in panels A-C, is denoted by the middle line in each rectangle. Whiskers represent the bottom 10th and top 90th percentiles. The Y-axis denotes relative expression (log2-ratio tumor vs. cerebellum controls). NS, not significant.