Table 1.
SNPs with P-value < 10−6 in original meta-analysis
| Trait | SNP | Chr | Position | Gene | Feature | A1 | A2 | Average EAF |
Discovery |
Replication |
Combined |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of subjects |
Age, sex adjusted | Age, sex, education adjusted |
No. of subjects |
Age, sex adjusted | Age, sex, education adjusted |
Age, sex adjusted | Age, sex, education adjusted |
|||||||||||||||
| Tests with summary values in beta (SE) | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | ||||||||||
| Trail A | rs9514964 | 13 | 109679886 | MY016 | ntron | A | G | 0.17 | 5429 | 0.048 (0.009) | 3.01E-07 | 0.044 (0.009) | 2.35E-06 | 9553 | −0.006 (0.007) | 0.37 | 0.007 (0.007) | 0.32 | 0.029 (0.007) | 1.55E-04 | 0.020 (0.006) | 3.03E-04 |
| rs9559465 | 13 | 109683883 | MY016 | ntron | A | G | 0.84 | −0.048 (0.010) | 3.30E-07 | −0.043 (0.009) | 2.59E-06 | 0.006 (0.008) | 0.43 | −0.007 (0.008) | 0.36 | −0.035 (0.008) | 1.58E-04 | −0.021 (0.006) | 2.35E-04 | |||
| rs1230154 | 4 | 99988659 | METAP1, ADH5 | ntergenic | T | C | 0.71 | −0.038 (0.007) | 7.69E-07 | −0.036 (0.008) | 1.64E-06 | 0.003 (0.006) | 0.63 | 0.001 (0.006) | 0.93 | −0.030 (0.007) | 9.34E-04 | −0.013 (0.005) | 4.83E-03 | |||
| Trail B | rs11082233 | 18 | 37265119 | PIK3C3, KC6 | ntergenic | T | C | 0.11 | 6210 | 0.073 (0.013) | 6.95E-08 | 0.061 (0.013) | 2.28E-06 | 10817 | −0.012 (0.010) | 0.25 | −0.017 (0.010) | 0.09 | 0.020 (0.008) | 1.73E-02 | 0.0123 (0.0079) | 0.12 |
| Phonemic fluency | rs6583634 | 8 | 143546590 | BAI1 | ntron | T | C | 0.15 | 13 454 | 1.046 (0.209) | 5.75E-07 | 0.914 (0.194) | 2.47E-06 | 12734 | −0.162 (0.230) | 0.48 | −0.009 (0.164) | 0.96 | 0.498 (0.155) | 1.00E-03 | 0.376 (0.125) | 0.0027 |
| rs10481393 | 8 | 143556168 | BAI1 | ntron | T | C | 0.15 | 1.050 (0.210) | 5.96E-07 | 0.914 (0.195) | 2.78E-06 | 0.068 (0.479) | 0.88 | −0.015 (0.183) | 0.937 | 0.891 (0.193) | 3.69E-06 | 0.420 (0.134) | 0.0016 | |||
| Semantic fluency | rs6587905 | 1 | 61093597 | C1orf87, NFIA | ntergenic | T | C | 0.16 | 6383 | 0.664 (0.129) | 2.80E-07 | 0.656 (0.126) | 2.09E-07 | 21860 | 0.091 (0.099) | 0.36 | 0.138 (0.077) | 0.071 | 0.303 (0.079) | 1.16E-04 | 0.280 (0.065) | 1.90E-05 |
| rs10115337 | 9 | 88711574 | LOC392358, GAS1 | ntergenic | T | C | 0.18 | −0.494 (0.100) | 8.02E-07 | −0.478 (0.098) | 9.88E-07 | −0.058 (0.079) | 0.46 | −0.083 (0.059) | 0.159 | −0.224 (0.062) | 2.88E-04 | −0.189 (0.050) | 1.65E-04 | |||
| rs10780801 | 9 | 88710941 | LOC392358, GAS1 | ntergenic | T | C | 0.82 | 0.493 (0.100) | 8.18E-07 | 0.477 (0.976) | 1.01E-06 | 0.055 (0.079) | 0.49 | 0.081 (0.059) | 0.166 | 0.223 (0.062) | 3.19E-04 | 0.189 (0.050) | 1.79E-04 | |||
| Tests with summary values in Z-scores | Z-score | P-value | Z-score | P-value | Z-score | P-value | Z-score | P-value | Z-score | P-value | Z-score | P-value | ||||||||||
| Stroop | 12 866 | 6381 | ||||||||||||||||||||
| LDST/DSST | rs664154 | 6 | 19099538 | RP1-239K6.1 | ntergenic | T | C | 0.24 | 32 070 | 5.22 | 1.84 E-07 | 4.79 | 1.67E-06 | 1311 | −0.96 | 0.34 | −1.06 | 0.29 | 5.03 | 5.01E-07 | 4.57 | 4.90E-06 |
| rs17518584 | 3 | 85687613 | CADM2 | ntron | T | C | 0.64 | 4.98 | 6.25 E-07 | 5.54 | 3.12E-08 | 2.23 | 0.03 | 1.95 | 0.05 | 5.43 | 5.56E-08 | 5.92 | 3.28E-09 | |||
| rs2734839 | 11 | 112791700 | DRD2 | ntron | T | C | 0.61 | 4.99 | 5.92 E-07 | 4.86 | 1.18E-06 | 0.55 | 0.58 | 0.20 | 0.84 | 5.13 | 2.95E-07 | 4.91 | 9.18E-07 | |||
| rs2118666 | 2 | 222808767 | PAX3 | ntron | T | G | 0.46 | −4.95 | 7.33E-07 | −4.25 | 2.17E-05 | 0.10 | 0.92 | −0.07 | 0.94 | −4.95 | 7.45E-07 | −4.26 | 2.08E-05 | |||
Abbreviations: A1, effect allele; A2, reference allele; Beta, beta coefficient of effect allele; Chr, Chromosome; EAF, effect allele frequency; SE, standard error of beta coefficient; LDST/DSST, Letter-Digit or Digit-Symbol Substitution Task; SNP, single-nucleotide polymorphism.