Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Prostate. 2015 Sep 29;76(1):97–113. doi: 10.1002/pros.23103

Figure 4. TMEFF2 expression does not affect androgen-dependent prostate growth.

Figure 4

Ten week old transgenic-TMEFF2 and non-transgenic mice were subjected to bilateral orchiectomy and after 20 days, time-release testosterone pellets were subcutaneously implanted. Two groups per genotype (n=5 per group) were formed by randomly selecting animals that were euthanized at 20 or 7 days post-pellet implantation. Animals from the sham group (n=2) underwent surgery but were not castrated or subject to testosterone pellet implantation. A) Body and prostates weights were recorded. Dissected prostate weights are expressed as percentage of the total body weight. B and C) Prostates from animals euthanized 7 days post pellet implantation were formalin-fixed, paraffin embedded, H&E stained or subjected to IHC with an antibody against the proliferation marker Ki67 and TMEFF2. In C) original magnification is 10x and in inserts is 60x.