Table 2.
Relationship between biomarker levels and World Health Organization functional class (n = 65)
| Biomarker | OR* | 95% CI | P Value |
|---|---|---|---|
| NT-pro-BNP (per 500-pg/ml increase) | 1.05 | 0.95–3.44 | 0.48 |
| vWF (per 50% increase) | 1.56 | 1.02–2.50 | 0.049 |
| Total cholesterol (per 50-mg/dl decrease) | 1.49 | 0.74–3.06 | 0.27 |
| HDL cholesterol (per 15-mg/dl decrease) | 2.11 | 1.23–3.83 | 0.009 |
| FMD (per 1% increase)† | 0.99 | 0.89–1.09 | 0.78 |
| CRP (per 1-μg/ml increase) | 0.97 | 0.92–1.03 | 0.39 |
| TNF (per 1-pg/ml increase)‡ | 1.07 | 0.99–1.33 | 0.54 |
| Triglycerides (per 50-mg/dl decrease) | 0.70 | 0.41–1.16 | 0.17 |
| sP-selectin (per 25-ng/ml increase) | 0.97 | 0.58–1.61 | 0.91 |
| BTG (per 40-IU/ml increase) | 1.18 | 0.81–1.73 | 0.37 |
| TX (per 800-pg/ml increase) | 1.11 | 1.01–1.23 | 0.041 |
| IL-6 (per 1-pg/ml increase)‡ | 1.22 | 1.04–1.60 | 0.10 |
Definition of abbreviations: BTG = β-thromboglobulin; CI = confidence interval; CRP = C-reactive protein; FMD = flow-mediated dilation; HDL = high-density lipoprotein; NT-pro-BNP = N-terminal pro-brain natriuretic peptide; OR = odds ratio; sP selectin = soluble P selectin; TNF = tumor necrosis factor; TX = thromboxane B2; vWF = von Willebrand factor
*
Adjusted for age, sex and etiology of pulmonary arterial hypertension.
†
n = 56.
‡
n = 62.