Table 3.
Relationship between biomarker levels and transplant-free survival (n = 65)
| Biomarker | HR* | 95% CI | P Value |
|---|---|---|---|
| NT-pro-BNP (per 500-pg/ml increase) | 1.13 | 1.05–1.21 | <0.001 |
| vWF (per 50% decrease) | 1.32 | 1.00–1.75 | 0.05 |
| Total cholesterol (per 50-mg/dl decrease) | 2.35 | 1.26–4.40 | <0.001 |
| HDL cholesterol (per 15-mg/dl decrease) | 1.42 | 0.78–2.60 | 0.25 |
| FMD (per 1% increase)† | 0.98 | 0.87–1.10 | 0.74 |
| CRP (per 1-μg/ml increase) | 0.97 | 0.90–1.05 | 0.43 |
| TNF (per 1-pg/ml increase)‡ | 0.99 | 0.95–1.02 | 0.48 |
| Triglycerides (per 50-mg/dl decrease) | 1.16 | 0.75–1.78 | 0.51 |
| sP-selectin (per 25-ng/ml increase) | 0.86 | 0.53–1.41 | 0.56 |
| BTG (per 40-IU/ml increase) | 1.07 | 0.77–1.47 | 0.69 |
| TX (per 800-pg/ml increase) | 1.01 | 0.93–1.09 | 0.85 |
| IL-6 (per 1-pg/ml increase)‡ | 1.00 | 0.95–1.05 | 0.97 |
Definition of abbreviations: BTG = β-thromboglobulin; CI = confidence interval; CRP = C-reactive protein; FMD = flow-mediated dilation; HDL = high-density lipoprotein; HR = hazard ratio; NT-pro-BNP = N-terminal pro-brain natriuretic peptide; sP selectin = soluble P selectin; TNF = tumor necrosis factor; TX = thromboxane B2; vWF = von Willebrand factor.
*
Adjusted for age, sex, etiology of pulmonary arterial hypertension, and 6-min-walk distance.
†
n = 56.
‡
n = 62.