TABLE 3.

Disease-free survival at 5 years according to the expression of tumor markers

Marker		Expression	n	DFS %	p
p21	UL	< 10%	20	34	0.204
	FL	≥ 10%	39	55
p27	UL	≤ 50%	45	40	0.040
	FL	> 50%	14	77
p53	FL	< 10%	28	59	0.177
	UL	≥ 10%	31	38
Cyclin D1	FL	< 10%	31	66	0.020
	UL	≥ 10%	28	30
EGFR	FL	< 10%	13	77	0.093
	UL	≥ 10%	46	41
Ki-67	UL	≤ 50%	46	42	0.131
	FL	> 50%	13	68
CD31*	UL	< 130	40	40	0.100
	FL	> 130	19	69
Number of UL per patient 1–4 vs 5–7		1–4	23	78	0.004
		5–7	36	32
Number of UL only for P27 & cyclin D1		0–1	39	65	0.002
		2	20	17

DFS = disease free survival; UL = unfavorable level of expression of tumor marker; FL = favorable level of expression of tumor marker; EGFR = pidermal growth factor receptor; n = number of patients;

^*in micro-vessels per mm².