Table 1.

Function annotations of putative causal and differentially expressed modules for the psychiatric disorders. The top 5 putative causal modules (first 5 rows) and top 5 differentially expressed modules (marked DE) are included. Five highest-weighted genes are listed for each module, and those genetically associated with psychiatric disorder are underlined.

ID	Module Function %	Top 5 Genes	Type	Differential Expression P-value			Enrichment of Putative Causal Genes, P-value			Module Ranking
				BP$	MD$	SZ$	BP$	MD$	SZ$
3	neuronal system; synaptic transmission; gated channel activity	SPHKAP, GABRA6, NEUROD1, CADPS2, CNTN6	Causal	0.23	0.42	0.49	4.E-12	2.E-07	1.E-12	34
13	axon guidance; nervous system development; glutamate receptor activity	DLK1, ZIC1, PTN, GNAL, DNER	Causal & DE	0.14	0.13	3.E-05	7.E-11	8.E-11	8.E-04	33
10	neuronal system; nervous system development; glutamate receptor activity	PMP2, SLC22A3, SLC17A8, KAL1, CHL1	Causal	0.90	0.72	0.09	2.E-07	7.E-11	5.E-06	42
4	neuronal system; nervous system development; voltage gated cation channel activity	RGS4, TESPA1, GDA, HTR2A, CDH9	Causal	0.61	0.10	0.18	7.E-04	2.E-10	4.E-06	41
23	GPCR downstream signaling; transmission of nerve impulse; receptor activity	RELN, MET, PENK, CALB1, GCNT4	Causal & DE	2.E-04	0.83	8.E-04	4.E-05	1.E-07	1.E-07	37
38	HIF1 TF pathway; signal transduction; drug binding	FKBP5, SLC14A1, PDK4, IL1RL1, ZBTB16	DE	9.E-03	0.14	3.E-08	0.05	0.35	0.26	13
6	oxidative phosphorylation; carbohydrate metabolic process; oxidoreductase activity	GSTT1, LAPTM4B, ATP6AP1, ATP6V0B, PITHD1	DE	2.E-03	0.25	1.E-03	0.21	0.62	0.43	7
28	cell cycle; cell cycle process; taste receptor activity	PI15, DLEU1, MSTN, FKBP14, SYCP2L	DE	2.E-05	0.79	0.24	0.20	0.87	0.66	4

^%For each module, three functional terms are provided. They are the most significant terms in canonical pathways, gene ontology (GO) biological process, and GO molecular functions.

^$BP: bipolar disorder; MD: major depression; SZ: schizophrenia.