Table 1.
Sample demographic and clinical characteristics (n= 37,972).
| Characteristics | Controls (n = 23,447) N (%) |
Invasive Cases (n = 14,525) N (%) |
p-value2 |
|---|---|---|---|
| Age (years) | |||
| Mean ± SD | 55.6 ± 11.9 | 58.1 ± 11.3 | <. 0001 |
| < 40 | 2027 (8.7) | 748 (5.2) | <. 0001 |
| 40–49 | 4771 (20.6) | 2544 (17.6) | |
| 50–59 | 7403 (31.9) | 4537 (31.3) | |
| 60–69 | 6098 (26.3) | 4324 (29.8) | |
| ≥ 70 | 2892 (12.5) | 2343 (16.2) | |
| Family history of ovarian cancer1 | |||
| No | 15425 (92.0) | 8634 (82.4) | <. 0001 |
| Yes | 1351 (8.0) | 1849 (17.6) | |
| Age at menarche (years) | |||
| Mean ± SD | 12.9 ± 1.7 | 12.8 ± 1.6 | 0.0314 |
| < 12 | 3128 (19.3) | 1856 (19.2) | 0.0772 |
| 12 | 3602 (22.2) | 2257 (23.4) | |
| 13 | 4357 (26.9) | 2621 (27.1) | |
| ≥ 14 | 5112 (31.6) | 2923 (30.3) | |
| Body mass inde × (kg/m2) | |||
| < 25 | 3834 (48.2) | 2528 (45.1) | 0.0006 |
| 25–29 | 2332 (29.3) | 1681 (30.0) | |
| ≥ 30 | 1797 (22.6) | 1396 (24.9) | |
| Oral contraceptive use | |||
| No | 6136 (37.5) | 4203 (43.7) | <. 0001 |
| Yes | 10230 (62.5) | 5419 (56.3) | |
| Histological subtypes | N/A | ||
| Serous | 8369 (57.6) | ||
| Endometroid | 2067 (14.2) | ||
| Clear Cell | 1024 (7.1) | ||
| Mucinous | 943 (6.5) | ||
| Others3 | 2122 (14.6) |
1
for the first degree relatives
2
t-test for a continuous variable and chi-square test for a categorical variable
3
Include mi × ed cell, other specified epithelial, undifferentiated, unknown (but known to be epithelial), nonepithelial, other or unknown if epithelial, or missing