Table 2.

Comparison of total number of significant knowledge features based on different dichotomized cholesterol phenotypes. Each element is the number of significant knowledge features from the functional annotation calculation (P<0.05).

Knowledge Type	CNV Type	Dichotomizing Cholesterol Phenotype			Shared Significant Knowledge^*
Knowledge Type		4^th Quartile vs. 3^rd, 2^nd, 1^st Quartiles	4^th, 3^rd Quartiles vs. 2^nd, 1^st Quartiles	4^th, 3^rd, 2^nd Quartiles vs. 1^st Quartile	Shared Significant Knowledge^*
Pathway	Dup	32	38	36	28
Pathway	Total CNV	20	10	21	13

GO	Dup	39	62	62	43
GO	Total CNV	50	38	58	26

Pfam	Dup	43	46	35	22
Pfam	Total CNV	63	57	68	20

Shared significant knowledge denotes the number of distinct knowledge that appears in at least more than two dichotomized phenotypes.