Table 3.
The list of significant pathways. Significant pathways associated with cholesterol were selected based on CNV burden data set (P<0.01). Continuous cholesterol phenotype was dichotomized at the 75th percentile in order to perform the proposed functional annotation pipeline, comparing CNVs in the top quartile (‘high’) with those in the bottom 3 quartiles (‘low’).
| CNV Type | Significant Pathways | Permutation P-value |
|---|---|---|
| Dup | Hepatitis C | 0.001998 |
| Toll-like receptor signaling pathway | 0.001998 | |
| Cytokine-cytokine receptor interaction | 0.006993 | |
| Shigellosis | 0.006993 | |
| RIG-I-like receptor signaling pathway | 0.007992 | |
| Influenza A | 0.00999 | |
| Total CNV | Toll-like receptor signaling pathway | 0.001 |
| Renal cell carcinoma | 0.002997 | |