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Success rate of the hERG primary screening using automated patch clamp assay. Cells with peak tail current amplitude bigger than 0.2 nA, seal resistance more than 30 MOhms, and percentage reduction of seal resistance (caused by first or second compound addition) lower than 25% were included for data analysis. MLSMR library 318 950 compounds in 1008 384-well compounds plates were screened. The averaged success rate was 96.08%±2.45%.
