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. 2016 Jan 4;37(1):111–123. doi: 10.1038/aps.2015.143

Figure 7.

Figure 7

Effect of compound physiochemical properties on hERG inhibitors and non-hERG inhibitors. (A) Octanol-water partition coefficient (ALogP); (B) Molecular weight (MW); (C) Rotatable bond number (RTB); (D) Hydrogen bond acceptor number (HBA); (E) Hydrogen bond donor number (HBD); (F) Topological polar surface area (TPSA); (G) Bar chart for the comparison between hERG active and inactive compounds. cP<0.01, student t-test. “Active” represents hERG inhibitors passing the statistical threshold (mean-3 SD) of vehicle control at 10 μmol/L; “Inactive” is for those compounds not passing the statistical threshold (mean-3 SD) of vehicle control at 10 μmol/L.