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Compound physiochemical properties affected potency of hERG inhibitors. (A) Octanol-water partition coefficient (ALogP); (B) Molecular weight (MW); (C) Rotatable bond number (RTB); (D) Hydrogen bond acceptor number (HBA); (E) Hydrogen bond donor number (HBD); (F) Topological polar surface area (TPSA). Dark blue bar: IC50<1 μmol/L; pink bar: 1 μmol/L<IC50<10 μmol/L; light blue bar: IC50>10 μmol/L; grey bar: hERG inactive compounds; white bar: hERG inactive compounds.
