Table 5.

Correlation between growth pattern and immunohistochemistry markers, including CK-7, TTF-1, Napsin-A, mutant EGFR, and ALK

Notes:

^*Including micro-papillary.

Abbreviations: CK-7, cytokeratin-7; TTF-1, thyroid transcription factor-1; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma kinase. The acinar, papillary, lepidic, and solid patterns had similar expression ratios on CK-7, TTF-1, Napsin-A, and mutant EGFRs, except ALK. The variant adenocarcinoma and poorly differentiated adenocarcinoma had lower expression ratios of CK-7, TTF-1, Napsin-A, and mutant EGFRs when compared to the acinar, papillary, lepidic, and solid patterns. The lepidic pattern had the lowest expression ratio of ALK, while the variant adenocarcinoma had the highest expression ratio of ALK.