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. 2016 Jan 18;9:1–10. doi: 10.2147/DMSO.S91245

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© 2016 Tojo et al. This work is published and licensed by Dove Medical Press Limited

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The uptake of exogenous human prorenin is enhanced in diabetic rats.

Notes: Immunostaining for human prorenin (brown color staining in A–D) in podocytes (arrows), proximal tubules (P), macula densa (asterisks), and distal nephrons (DT) including cortical collecting ducts, appeared enhanced in diabetic rats (B and D) compared with controls (A and C). Bar: 100 μm. A Western blot analysis for human prorenin demonstrating an increased uptake of human prorenin in the whole kidney homogenates (E and F) and also in glomerular and tubular fractions in diabetic rats (G). ^#P<0.01 vs control.

Abbreviations: DM, streptozotocin-induced diabetes mellitus rats; lc, loading control.