Table 1. Known DNA damage sensitive strains for genotoxins.
A summary of genotoxins, the lesions they produce, and sensitive strains. The media used for this protocol is also indicated.
| Genotoxins | Lesions | Sensitive mutants | Media |
|---|---|---|---|
| UV | Pyrimidine dimer | slx-1(tm2644) (Saito et al., 2012), him-18(tm2181) (Saito et al., 2012) | Solid |
| IR | DSBs | him-18(tm2181) (Saito et al., 2012), brc-1(tm1145) (Ward et al., 2007), ztf-8(tm2176) (Kim and Colaiacovo, 2014) | Solid |
| HU | Replication Fork Stall | clk-2(mn159) (Bailly et al., 2010), ztf-8(tm2176) (Kim and Colaiacovo, 2014) | Solid |
| CPT | SSBs | him-18(tm2181) (Saito et al., 2012), brc-1(tm1145) (Ward et al., 2007) | Liquid |
| HN2 | ICL | brc-1(tm1145) (Ward et al., 2007), slx-1(tm2644) (Saito et al., 2012) | Liquid |