Table 3. Kinetically derived parameters for the various solutes as derived from measured solute concentrations during a single midweek dialysis session.
Solute | V1(L) | Vtot(L) | K21(mL/min) |
---|---|---|---|
urea | 10.2 ± 5.6 | 32.9 ± 8.1 | 457 ± 175 |
PCG | 8.2 ± 2.4 | 18.9 [15.7;25.2] | 103 ± 47 α |
HA | 8.4 ± 3.8 | 20.9 ± 4.7 α | 169 ± 81 α |
IAA | 4.9 ± 1.5 αβ | 24.7 ± 10.6 | 123 ± 46 α |
IS | 3.7 [3.7;4.2] αβ | 16.5 ± 6.5 α | 85 ± 72 α |
PCS | 3.8 ± 0.9βγ | 10.4 [9.8;15.1] αδ | 87 ± 44 α |
V1: plasmatic volume, Vtot: total distribution volume, K21: intercompartment clearance. PCG: p-cresylglucuronide, HA: hippuric acid, IAA: indole acetic acid, IS: indoxyl sulfate, PCS: p-cresylsulfate. P<0.05:
αversus urea;
βversus PCG;
γversus HA;
δversus IAA.