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. 2016 Jan 22;11(1):e0147006. doi: 10.1371/journal.pone.0147006

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© 2016 Fu et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Representative SIM images of three different tissue types commonly found in margin images: tumor, muscle, and adipose tissues. For the smaller ROIs, both the sectioned (structured illumination) and widefield (standard illumination) images are shown to demonstrate the enhanced contrast that SIM provides. Examples of H&E micrographs are also shown, but it should be noted the H&E is not taken from the exact site of the corresponding SIM images because specific site level fiducial markers were not used in this study. Scale bars are 200 μm.