Table 4.
Hazard ratios for heart failure according to classification to estimated glomerular filtration rate categories by the CKD-EPI equation and MDRD satudy equation at baseline among African American and White patients with diabetes
| eGFRMDRD categories (ml/min/1.73 m2) | eGFRCKD-EPI categories (ml/min/1.73 m2)
|
|||||
|---|---|---|---|---|---|---|
| ≥ 90 | 75–89 | 60–74 | 30–59 | < 30 | ||
| Both African American and White Patients | ||||||
| ≥ 90 | No. cases | 1 902 | 90 | – | – | – |
| Person-year | 93 647 | 2 936 | – | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 1.00 | 1.03 (0.83–1.28) | – | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.00 | 0.95 (0.77–1.18) | – | – | – | |
| 75–89 | No. cases | 83 | 901 | 76 | – | – |
| Person-year | 5 126 | 35 142 | 2 284 | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 0.89 (0.72–1.11) | 1.12 (1.04–1.22) | 1.02 (0.80–1.29) | – | – | |
| Multivariable adjustment HR (95% CI)† | 0.94 (0.75–1.17) | 1.11 (1.02–1.20) | 1.01 (0.80–1.28) | – | – | |
| 60–74 | No. cases | – | 53 | 780 | 78 | – |
| Person-year | – | 2 365 | 25 210 | 1 847 | – | |
| Age- and sex-adjusted HR (95% CI)† | – | 1.20 (0.91–1.58) | 1.28 (1.17–1.39) | 1.34 (1.06–1.69) | – | |
| Multivariable adjustment HR (95% CI)† | – | 1.26 (0.96–1.66) | 1.20 (1.10–1.30) | 1.25 (0.99–1.58) | – | |
| 30–59 | No. cases | – | – | 21 | 864 | 29 |
| Person-year | – | – | 723 | 17 291 | 375 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | 1.37 (0.89–2.11) | 1.88 (1.73–2.06) | 2.58 (1.38–3.73) | |
| Multivariable adjustment HR (95% CI)† | – | – | 1.38 (0.89–2.12) | 1.70 (1.56–1.86) | 2.08 (1.44–3.02) | |
| < 30 | No. cases | – | – | – | – | 166 |
| Person-year | – | – | – | – | 2 020 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | – | 3.53 (3.01–4.14) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | – | 3.10 (2.64–3.65) | |
| African American patients | ||||||
| ≥ 90 | No. cases | 1 248 | 77 | – | – | – |
| Person-year | 64 032 | 2 665 | – | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 1.00 | 1.10 (0.87–1.40) | – | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.00 | 1.02 (0.81–1.30) | – | – | – | |
| 75–89 | No. cases | 18 | 468 | 55 | – | – |
| Person-year | 1 550 | 20 257 | 1 932 | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 0.74 (0.47–1.18) | 1.13 (1.01–1.25) | 1.01 (0.76–1.33) | – | – | |
| Multivariable adjustment HR (95% CI)† | 0.71 (0.45–1.14) | 1.12 (1.00–1.24) | 1.04 (0.79–1.38) | – | – | |
| 60–74 | No. cases | – | 1 | 393 | 67 | – |
| Person-year | – | 60 | 12 714 | 1 643 | – | |
| Age- and sex-adjusted HR (95% CI)† | – | 1.24 (0.18–8.84) | 1.44 (1.28–1.61) | 1.52 (1.18–1.96) | – | |
| Multivariable adjustment HR (95% CI)† | – | 1.20 (0.16–8.56) | 1.34 (1.18–1.50) | 1.40 (1.08–1.81) | – | |
| 30–59 | No. cases | – | – | – | 391 | 17 |
| Person-year | – | – | – | 8 547 | 268 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | 1.98 (1.75–2.23) | 2.61 (1.61–4.22) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | 1.79 (1.58–2.02) | 1.90 (1.17–3.08) | |
| < 30 | No. cases | – | – | – | – | 94 |
| Person-year | – | – | – | – | 1 248 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | – | 3.57 (2.89–4.41) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | – | 3.18 (2.57–3.94) | |
| White patients | ||||||
| ≥ 90 | No. cases | 654 | 13 | – | – | – |
| Person-year | 29 615 | 271 | – | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 1.00 | 1.05 (0.60–1.83) | – | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.00 | 0.95 (0.55–1.66) | – | – | – | |
| 75–89 | No. cases | 65 | 433 | 21 | – | – |
| Person-year | 3 576 | 14 885 | 353 | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 0.94 (0.73–1.22) | 1.09 (0.97–1.24) | 1.36 (0.87–2.11) | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.02 (0.79–1.32) | 1.08 (0.96–1.23) | 1.14 (0.73–1.79) | – | – | |
| 60–74 | No. cases | – | 52 | 387 | 11 | – |
| Person-year | – | 2 304 | 12 496 | 204 | – | |
| Age- and sex-adjusted HR (95% CI)† | – | 1.25 (0.95–1.67) | 1.11 (0.98–1.27) | 0.95 (0.52–1.75) | – | |
| Multivariable adjustment HR (95% CI)† | – | 1.33 (1.00–1.77) | 1.06 (0.93–1.21) | 1.07 (0.59–1.98) | – | |
| 30–59 | No. cases | – | – | 21 | 473 | 12 |
| Person-year | – | – | 675 | 8 744 | 106 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | 1.40 (0.91–2.17) | 1.74 (1.53–1.99) | 2.35 (1.32–4.21) | |
| Multivariable adjustment HR (95% CI)† | – | – | 1.38 (0.89–2.14) | 1.58 (1.39–1.81) | 2.16 (1.20–3.88) | |
| < 30 | No. cases | – | – | – | – | 72 |
| Person-year | – | – | – | – | 772 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | – | 3.44 (2.69–4.39) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | – | 3.05 (2.38–3.91) | |
| Age ≥ 60 years | ||||||
| ≥ 90 | No. cases | 184 | 66 | – | – | – |
| Person-year | 6 412 | 2 028 | – | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 1.00 | 1.08 (0.81–1.43) | – | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.00 | 0.95 (0.72–1.27) | – | – | – | |
| 75–89 | No. cases | 19 | 215 | 62 | – | – |
| Person-year | 642 | 6 139 | 1 669 | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 0.97 (0.60–1.58) | 1.11 (0.91–1.36) | 1.10 (0.82–1.48) | – | – | |
| Multivariable adjustment HR (95% CI)† | 0.98 (0.60–1.58) | 1.08 (0.88–1.32) | 1.06 (0.79–1.42) | – | – | |
| 60–74 | No. cases | – | – | 245 | 54 | – |
| Person-year | – | – | 5 906 | 1 203 | – | |
| Age- and sex-adjusted HR (95% CI)† | – | – | 1.28 (1.05–1.56) | 1.29 (0.94–1.76) | – | |
| Multivariable adjustment HR (95% CI)† | – | – | 1.15 (0.95–1.41) | 1.17 (0.85–1.60) | – | |
| 30–59 | No. cases | – | – | 6 | 366 | 17 |
| Person-year | – | – | 179 | 6 929 | 187 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | 1.18 (0.52–2.68) | 1.57 (1.31–1.89) | 2.31 (1.39–3.83) | |
| Multivariable adjustment HR (95% CI)† | – | – | 1.19 (0.52–2.69) | 1.43 (1.19–1.72) | 1.82 (1.10–3.04) | |
| < 30 | No. cases | – | – | – | – | 63 |
| Person-year | – | – | – | – | 504 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | – | 3.90 (2.92–5.20) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | – | 2.87 (2.14–3.86) | |
| Age < 60 years | ||||||
| ≥ 90 | No. cases | 1 718 | 24 | – | – | – |
| Person-year | 87 235 | 908 | – | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 1.00 | 1.05 (0.70–1.57) | – | – | – | |
| Multivariable adjustment HR (95% CI)† | 1.00 | 1.02 (0.68–1.53) | – | – | – | |
| 75–89 | No. cases | 64 | 686 | 14 | – | – |
| Person-year | 4 484 | 29 003 | 615 | – | – | |
| Age- and sex-adjusted HR (95% CI)† | 0.90 (0.70–1.16) | 1.12 (1.02–1.22) | 0.86 (0.51–1.46) | – | – | |
| Multivariable adjustment HR (95% CI)† | 0.93 (0.72–1.20) | 1.10 (1.00–1.20) | 0.89 (0.52–1.50) | – | – | |
| 60–74 | No. cases | – | 53 | 535 | 24 | – |
| Person-year | – | 2 362 | 19 304 | 643 | – | |
| Age- and sex-adjusted HR (95% CI)† | – | 1.26 (0.95–1.66) | 1.24 (1.12–1.37) | 1.55 (1.04–2.33) | – | |
| Multivariable adjustment HR (95% CI)† | – | 1.32 (1.00–1.75) | 1.17 (1.06–1.30) | 1.66 (1.10–2.49) | – | |
| 30–59 | No. cases | – | – | 15 | 498 | 12 |
| Person-year | – | – | 544 | 10 362 | 187 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | 1.41 (0.85–2.35) | 2.13 (1.92–2.36) | 2.64 (1.49–4.66) | |
| Multivariable adjustment HR (95% CI)† | – | – | 1.41 (0.84–2.34) | 1.86 (1.68–2.06) | 2.01 (1.14–3.55) | |
| < 30 | No. cases | – | – | – | – | 103 |
| Person-year | – | – | – | – | 1 516 | |
| Age- and sex-adjusted HR (95% CI)† | – | – | – | – | 3.28 (2.69–4.00) | |
| Multivariable adjustment HR (95% CI)† | – | – | – | – | 3.11 (2.54–3.80) | |
*
Adjusted for age, sex, smoking, income, type of insurance, BMI, systolic blood pressure, HbA1c, LDL cholesterol, triglycerides, myocardial infarction, use of antihypertensive drugs, use of diabetes medications, and use of cholesterol-lowering agents
†
Also adjusted for race.