Table 1. Dimensional model parameters and their estimates.

Parameter	Meaning	Value (original units)	Value (non-dimensionalised)	Reference
D c	Oxygen diffusion coefficient	1.0 × 10−5 cm2 s−1	2.304 × 104 cell cycle−1	[57]
r c	Maximal oxygen consumption rate	4.6 × 10−16 mol cell−1 s−1	51.54 cell cycle−1	[53]
r p	Proliferative oxygen consumption	5 × r c		[53]
Δx	Average cell diameter	50 μm	1 cell diameter	[55]
Δt	Oxygen update time step	0.25 s	1 cell cycle / 230,400	—
τ	Average cell cycle time	16 h	1 cell cycle	[54]
c ap	Hypoxic threshold	5.14 × 10−14 mol−1 cell−1	0.1	[56]
K m	Effective Michaelis-Menten constant	5.14 × 10−15 mol−1 cell−1	0.01	[58]
c max	Arterial oxygen concentration	5.14 × 10−13 mol−1 cell−1	1	[59]
μ H	Healthy tissue metabolic constant	1	1	—
μ cancer/μ H	Cancer metabolic ratio	2	2	[60]
p d	Probability of death when c < c ap	0.25 cell cycle−1	0.25 cell cycle−1	—
p H	Probability of division for healthy cell	0.005	—	—
p T	Probability of division for tumour cell	0.01	—	—
c p	Quiescence threshold	1.1c ap	0.11	—
K OER	Effective OER constant	3.28	3.28	[13, 40, 61]
OERα,min = OERβ,min	OER min constant	1	1	[13, 40, 61]
OERα,max	OERα max constant	1.75	1.75	[13, 40, 61]
OERβ,max	OERα max constant	3.25	3.25	[13, 40, 61]