Fig 2. Comparison of performance on rotarod test.

Mean latency to fall times for each mouse were normalized to the first week of testing (Day -21). Bars indicate the standard error of the mean. Three tests were performed prior to surgery at -21, -14, and -7 days prior to surgery and then 3, 7, 14, 21 and 28 days after surgery. No significant differences were observed between treatment groups (p = 0.26), which include GRIN lens implant (GRIN Lens), cranial window (No Lens), and sham surgery (Anesthesia Only) groups (n = 5 mice per treatment group). Only the effect of time was significant (p = 0.0002). The upward trend in latency times suggests a learning effect.