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Effects of combination therapy on tumour burden. (A) Analysis of total tumour area (mm2) performed on a minimum of 2 non-serial sections per sample using a 4x objective. One way ANOVA and Tuckey post test, * is p<0.05, ** is p<0.01, *** is p<0.001, ns=not significant. (B) Example Goldner's trichrome stained section depicting extra- and intra-osseous tumour foci. (C) Number of mice on day 23 with intra- and extra-osseous tumour colony detected by histology.
