FIG. 1.

Workflow of simulation, processing and fitting: The Bloch–McConnell equations coupled with perfusion were solved for a range of sequence parameters. Noise was added to the resulting free induction decay signals. The signal of each metabolite was estimated via HHFW integration of the spectral peak at each time point. The signal evolution curves were fit using a two-site model to determine fit exchange. The fitted $\widehat{k_{pl}}$ was then compared with the assumed (driving) value to determine the accuracy of exchange rates measurements for a given combination of sequence parameters.