TABLE I.

Physical and biologic constants that were used in simulation.

Parameter	Symbol	Value
Gyromagnetic ratio	γ	$67.262\times 10^6\text{rad}/\left(\mathrm{s}\text{T}\right)$
Vascular extravasation rate	kve	0.02 s−1
Extravascular volume fraction	ve	0.91
Pyruvate T1 relaxation time	T1,Pyr	43 s
Lactate T1 relaxation time	T1,Lac	33 s
$T_2^{*}$ Relaxation time for both pyruvate and lactate	$T_2^{*}$	20 ms
Vascular input function	$\mathrm{\Gamma }\left(t\right)$	$t^{1.8}exp\left(-t/4.5\right)$