Fig. 3.

Functional relevance of syndecan-1 (SDC1) modulation. Cells were serum starved 12 h prior to and during treatment. After DEX-treatment (10⁻⁶ M, 72 h) the (A) viability of MCF-7 cells was analyzed. Additionally we investigated (B) apoptosis and (C) migration of DEX-treated MCF-7 cells. (D) Cell viability was assessed after SDC1 knock-down in MCF-7, T-47D and MDA-MB-231 cells. N=3, ^⁎p<0.05, ^⁎⁎p<0.01, DEX—dexamethasone, MDA-MDA-MB-231, RU—RU-486, SDC1 kd—syndecan-1 knock-down, and scr. C—scrambled control.