Fig. 3.

Anti-adhesive effects are mediated by inhibited geranylgeranylation. (A) MDA-231 cells were treated with 5 µM GGTI-298 or 0.1 µM FTI-277 for 24 h. Adhesion on type I collagen, gelatin and vitronectin coated plates was assessed afterwards. (B) MDA-231 cells were treated either with mevalonate (10 µM), FPP (100 µM) or GGPP (100 µM) 2 h prior to zoledronic acid (100 µM) or zoledronic acid alone. Data are presented as the percentage adhesion relative to control treated cells, and are mean±SD of 3–4 independent experiments. ^*p<0.05; ^***p<0.001.