Table 1.
Demographic Characteristics of Parkinson’s Disease (PD) Cases, Unaffected Siblings, and Unrelated Controls
| General Characteristics | PD Case-Sibling Pairs
|
PD Case-Unrelated Control Pairs
|
All PD Case-Control Pairs
|
|||
|---|---|---|---|---|---|---|
| PD Cases | Sibling Controls | PD Cases | Unrelated Controls | PD Cases | All Controls | |
| Total sample, n | 654 | 654 | 449 | 449 | 1,103 | 1,103 |
| Men, n (%) | 417 (63.8) | 329 (50.3) | 290 (64.6) | 290 (64.6) | 707 (64.1) | 619 (56.1) |
| Women, n (%) | 237 (36.2) | 325 (49.7) | 159 (35.4) | 159 (35.4) | 396 (35.9) | 484 (43.9) |
| Age at onset of PD, median year (range) | 60.4 (28.2 – 86.9) | — | 64.7 (23.3 – 88.0) | — | 62.2 (23.3 – 88.0) | — |
| Age at study, median year (range)a | 66.3 (30.8 – 91.4) | 65.1 (32.0 – 90.4) | 70.3 (44.5 – 90.4) | 71.8 (44.9 – 92.8) | 68.0 (30.8 – 91.4) | 67.6 (32.0 – 92.8) |
| Duration of PD, median year (range) | 3.2 (0.1 – 23.6) | — | 3.9 (0 – 54.2) | — | 3.4 (0 – 54.2) | — |
| Region of origin of parentsb | ||||||
| Both parents of European origin, n (%) | 570 (87.2) | 557 (85.2) | 361 (80.4) | 391 (87.1) | 931 (84.4) | 948 (85.9) |
| Both parents Northern European, n (%) | 154 (27.0) | 148 (26.6) | 116 (32.1) | 126 (32.2) | 270 (29.0) | 274 (28.9) |
| Both parents Central European, n (%) | 233 (40.9) | 219 (39.3) | 119 (33.0) | 124 (31.7) | 352 (37.8) | 343 (36.2) |
| Both parents Southern European, n (%) | 3 (0.5) | 3 (0.5) | 3 (0.8) | 4 (1.0) | 6 (0.6) | 7 (0.7) |
| Both parents European, mixed region, n (%) | 180 (31.6) | 187 (33.6) | 123 (34.1) | 137 (35.0) | 303 (32.5) | 324 (34.2) |
| Only one parent of European origin, n (%)c | 53 (8.1) | 61 (9.3) | 60 (13.4) | 41 (9.1) | 113 (10.2) | 102 (9.2) |
| One parent declared “American”, n (%)d | 2 (0.3) | 1 (0.2) | 1 (0.2) | 4 (0.9) | 3 (0.3) | 5 (0.5) |
| Both parents declared “American”, n (%)d | 19 (2.9) | 20 (3.1) | 13 (2.9) | 7 (1.6) | 32 (2.9) | 27 (2.4) |
| Both parents Asian, n (%) | 3 (0.5) | 3 (0.5) | 5 (1.1) | 0 (0.0) | 8 (0.7) | 3 (0.3) |
| Both parents Mexican, n (%) | 1 (0.2) | 1 (0.2) | 1 (0.2) | 1 (0.2) | 2 (0.2) | 2 (0.2) |
| Unknown, n (%) | 6 (0.9) | 11 (1.7) | 8 (1.8) | 5 (1.1) | 14 (1.3) | 16 (1.5) |
a
Age at blood draw.
b
Self-reported by subjects. “Northern European” includes Scandinavian, Swedish, Norwegian, Finnish, Danish, Irish, or British origins. “Central European” includes French, Belgian, Dutch, Swiss, Luxemburgian, German, Austrian, Hungarian, Polish, Czechoslovakian, or Russian origins. “Southern European” includes Italian, Spanish, Portuguese, Greek, or Yugoslavian origins.
c
Includes subjects for whom origin of one parent is unknown.
d
These subjects were all Caucasians and not Native Americans.