Table 2.
Demographic Characteristics of Parkinson’s Disease (PD) Cases, Siblings, and Unrelated Controls
| General characteristics | PD Case – Sibling Pairs | PD Case-Unrelated Control Pairs | All PD Case- Control Pairs | |||
|---|---|---|---|---|---|---|
|
| ||||||
| PD Cases | Sibling Controls | PD Cases | Unrelated Controls | PD Cases | All Controls | |
| Total sample, n | 653 | 653 | 445 | 445 | 1,098 | 1,098 |
| Men, n (%) | 417 (63.8) | 329 (50.4) | 288 (64.7) | 288 (64.7) | 705 (64.2) | 617 (56.2) |
| Women, n (%) | 236 (36.1) | 324 (49.6) | 157 (35.3) | 157 (35.3) | 393 (35.8) | 481 (43.8) |
| Age at onset of PD, median (range) | 60.4 (28.2–86.9) | -- | 64.6 (23.3–88.0) | -- | 62.2 (23.3–88.0) | -- |
| Age at study, median (range)1 | 66.3 (30.8–91.4) | 65.1 (32.0–90.4) | 70.3 (44.5–90.4) | 71.8 (44.9–92.8) | 68.0 (30.8–91.4) | 67.6 (32.0–92.8) |
| Ethnicity: | ||||||
| Both parents of European origin, n(%) | 570 (87.3) | 557 (85.3) | 357 (80.2) | 388 (87.2) | 927 (84.4) | 945 (86.1) |
| One parents of European origin, n(%) | 52 (8.0) | 60 (9.2) | 60 (13.5) | 41 (9.2) | 112 (10.2) | 101 (9.2) |
| Family History of PD | ||||||
| First degree family history of PD, n (%) | 73 (16.4) | -- | 106 (16.2) | -- | 179 (16.3) | -- |
| At least third degree family history of PD, n (%) | 112 (27.4) | -- | 193 (29.6) | -- | 315 (28.7) | -- |
1
Age at blood draw