Table 3.

SNP-SNP Interactions with Marginal Evidence of Association with PD Susceptibility (uncorrected p < 0.05)

SNP1	Gene1	SNP1 OR (95% CI)	SNP1 P value	SNP2	Gene2	SNP2 OR (95% CI)	SNP2 P value	Interaction P value
rs16940758	MAPT	1.21 (0.99 – 1.47)	0.0595	rs2583959	SNCA	1.18 (1.00 – 1.39)	0.0492	0.0049
rs2435211	MAPT	1.16 (0.99 – 1.35)	0.0677	rs3775423	SNCA	1.38 (1.07 – 1.79)	0.0136	0.0105
rs17484286	LRRK2	0.73 (0.57 – 0.94)	0.0143	rs3775423	SNCA	1.42 (1.10 – 1.85)	0.0071	0.0117
rs17484286	LRRK2	0.72 (0.56 – 0.92)	0.0093	rs3775439	SNCA	1.21 (0.97 – 1.50)	0.0914	0.0192
rs8079215	MAPT	1.16 (0.99 – 1.36)	0.0713	rs3775423	SNCA	1.41 (1.09 – 1.82)	0.0083	0.0214
rs17484286	LRRK2	0.73 (0.57 – 0.94)	0.0142	REP1-263	SNCA	1.35 (1.02 – 1.78)	0.0348	0.0233
rs7307562	LRRK2	1.11 (0.96 – 1.29)	0.1658	rs9995651	SNCA	1.31 (0.92 – 1.86)	0.1270	0.0383
rs17466521	LRRK2	0.88 (0.75 – 1.05)	0.1522	rs2572324	SNCA	1.23 (1.05 – 1.44)	0.0120	0.0416
rs17484286	LRRK2	0.73 (0.57 – 0.94)	0.0142	rs9995651	SNCA	1.33 (0.93 – 1.88)	0.1138	0.0445
rs10784486	LRRK2	0.89 (0.76 – 1.05)	0.1660	rs2435211	MAPT	1.15 (0.98 – 1.35)	0.0770	0.0490

P-values are not corrected for multiple testing. For consistency, all results in a given row are based on the same sample that contributed to the interaction analysis, with complete data at both SNPs under consideration.