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HCV non-structural proteins with three-dimensional structures determined and published in the literature
| Polypeptide | Function | Reference |
| NS3 protease domain | Protease that cleaves HCV polyprotein at several locations | 75, 76 |
| NS4A (complexed to NS3) | Cofactor for NS3 protease | 76 |
| NS3 RNA helicase domain | Unwinds viral RNA | 77, 78 |
