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. 2000 Apr 15;6(2):157–168. doi: 10.3748/wjg.v6.i2.157

Figure 6.

Figure 6

Disruption of the entero-pancreatic feedback loop. A: Normal condition: Brake of CCK release. Direct brake (trypsin, chymotripsin) of the CCK-releasing peptide and of the monitor peptide (a). Indirect brake (bilis). Stabilization of trypsin and chymot rypsin (b). Bile-pancreatic secretion activation of a negative duodeno-pancre atic reflex (c). B: Bile-pancreatic duct obstruction condition-Loss of the normal bile-pancreatic secretion-evoked brake of CCK release. Stone impactation in the Vaterian papilla (a). CCK-induced paracrine-neural duode no-pancreatic reflex (b). CCK-elicited hormonal activation of pancreon units (c). Neural (b) and hormonal (c) mechanisms. Neural (b) and hormonal (c) pathway to the CCK-evoked supramaximal stimulation of the acinar component of the panc reon units.