Mean (95 % CI) change from baseline in DAS28-CRP and MBDA score. MBDA scores (at weeks 12 and 24) and DAS28-CRP (at weeks 4, 12, and 24) were statistically significantly improved from baseline, based on 95 % CI being entirely <0. BL baseline, DAS28-CRP 28-joint disease activity score with C-reactive protein, MBDA multi-biomarker disease activity