Fig. 3.

Percentage changes in MBDA biomarker concentrations from baseline to week 24. Percentage changes in concentrations of individual biomarkers from baseline to week 24 for patients with MBDA results at both time points (n = 35). Biomarkers are sorted by median percentage change from baseline. Each box represents the interquartile range (IQR; 25th to 75th percentiles), with the median indicated by a line, the mean indicated by a diamond, and the whiskers extending to the last data values within the 1.5 × IQR range; circles indicate outliers (defined as points beyond the 1.5 × IQR). Seven values with large percentage increases from baseline to week 24 were analyzed, but are not shown: 2 for SAA (1728 % and 2427 %), 1 for CRP (3247 %), 2 for EGF (1840 % and 4000 %), and 2 for IL-6 (1940 % and 2772 %). BL baseline, CRP C-reactive protein, EGF epidermal growth factor, IL interleukin, MMP matrix metalloproteinase, SAA serum amyloid A, TNFR tumor necrosis factor receptor, VCAM vascular cell adhesion molecule, VEGFA vascular endothelial growth factor α, YKL-40 human cartilage glycoprotein 39