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. 2016 Jan 22;27:63. doi: 10.1007/s10856-015-5656-3
Targeted application Materials/manufacturing techniques Function of fibrous structure Biological cues/clinical application References
Knitting
 Vascular grafts PGA knitted fibers + l-lactide/PCL copolymer sponge with PGA/PCL copolymer monofilament reinforcement Initial reinforcement;
Elasticity for shape adaption
[155, 156]
Knitted polyester; commercially available vascular grafts Mechanical stability Fibronectin SDF-1 alpha [143]
Knitted PGA/collagen microsponge + woven PLLA (outer layer) Outer layer: reinforcement; inner layer: porous environment promoting in situ cellularization [205, 206]
Knitted PLGA (90:10) + collagen microsponge Mechanical stability [207]
 Nerve regeneration Aligned PLGA fibers + alginate hydrogel contained in knitted PLA sheath coated with electrospun PLA nanofibers Mechanical stability;
Controlled poresize adjusted to nerve regeneration;
Aligned fibers for cell guidance
Neurothropic factors (NT-3 or BDNF with LIF, SMDF and MGF-1) [63]
 Dermal grafts Warp-knitted PLGA-mesh + collagen/chitosan sponge Mechanical stability [49, 54, 159]
 Tendon regeneration Knitted silk + collagen sponge Mechanical stability;
provides space for tissue ingrowth
SDF-1 alpha [48]
 Esophagus replacement Porous collagen + PCL knitting, tubularized by sutures Mechanical stability [60]
 Hernia repair PLGA (90:10) knit + collagen sponge Mechanical stability [208]
 Small joint reconstruction Knitted poly-L/D-lactide (P(L/D)LA) 96/4 Porous environment for cell ingrowth;
Mechanical strength
Clinical study [200204]
 Calvarial bone healing Knitted P(L/D)LA 96/4 Mechanical stability FGF-1 [209, 210]
Weaving
 Nerve regenerattion Biodegradable glass fabric Mechanical stability [211]
 Vascular graft Woven tubes (luminal Ø 4 mm), with double-layered PGA (core)/PLLA (sheath) fibers + collagen microsponges Mechanical stability;
3D porous environment
[147, 164]
 Fascia replacement/hernia repair Handwoven meshes from native dragline silk of Nephila spp. Mechanical stability [59]
 Tendon/Ligament repair Layered PLLA fabrics; side A: smooth surface, side B: pile-finished surface Mechanical stability;
Control of cell migration/adhesion by adjusted surface structures
[165]
Woven PLA pad Mechanical stability [212]
Woven PLA (commercially available material) Mechanical stability; Host tissue deposition [166]
Braiding
 Nerve regeneration PGA tube + collagen sponge Mechanical stability Clinical studies [179181, 176]
Braid of PLLA and PGA yarns (1:1) + collagen coating Mechanical stability;
PLLA for prolonged reinforcement
[50]
Microbraided PLGA (10:90) tubes Mechanical stability [213]
 Tendon/ligament repair Lyophilized human fascia reinforced by braided PLLA/PGA fibers Mechanical stability [171, 172]
PLLA braid + gelatin hydrogel + collagen membrane Mechanical stability bFGF [146]
PLLA 3D square braid Mechanical stability;
Tissue ingrowth
[173]
Non-woven
 Nerve regeneration poly[(R)-3-hydroxybutyrate] (PHB) non-woven Mechanical stability Clinical study [196]
Oriented silk-fibroin filaments Mechanical stability;
Aligned fibers for cell guidance
[195]
 Cartilage repair PGA felt + hyaluronic acid/hyaluronan Mechanical stability;
Porous environment
Allogeneic/autologous serum [144, 145]
 Tendon/ligament repair PGA sheet Mechanial stability;
Tissue ingrowth
[193]
Chitin sheet Mechanial stability;
Tissue ingrowth
[194]