Targeted application | Materials/manufacturing techniques | Function of fibrous structure | Biological cues/clinical application | References |
---|---|---|---|---|
Knitting | ||||
Vascular grafts | PGA knitted fibers + l-lactide/PCL copolymer sponge with PGA/PCL copolymer monofilament reinforcement | Initial reinforcement; Elasticity for shape adaption |
– | [155, 156] |
Knitted polyester; commercially available vascular grafts | Mechanical stability | Fibronectin SDF-1 alpha | [143] | |
Knitted PGA/collagen microsponge + woven PLLA (outer layer) | Outer layer: reinforcement; inner layer: porous environment promoting in situ cellularization | – | [205, 206] | |
Knitted PLGA (90:10) + collagen microsponge | Mechanical stability | – | [207] | |
Nerve regeneration | Aligned PLGA fibers + alginate hydrogel contained in knitted PLA sheath coated with electrospun PLA nanofibers | Mechanical stability; Controlled poresize adjusted to nerve regeneration; Aligned fibers for cell guidance |
Neurothropic factors (NT-3 or BDNF with LIF, SMDF and MGF-1) | [63] |
Dermal grafts | Warp-knitted PLGA-mesh + collagen/chitosan sponge | Mechanical stability | – | [49, 54, 159] |
Tendon regeneration | Knitted silk + collagen sponge | Mechanical stability; provides space for tissue ingrowth |
SDF-1 alpha | [48] |
Esophagus replacement | Porous collagen + PCL knitting, tubularized by sutures | Mechanical stability | – | [60] |
Hernia repair | PLGA (90:10) knit + collagen sponge | Mechanical stability | – | [208] |
Small joint reconstruction | Knitted poly-L/D-lactide (P(L/D)LA) 96/4 | Porous environment for cell ingrowth; Mechanical strength |
Clinical study | [200–204] |
Calvarial bone healing | Knitted P(L/D)LA 96/4 | Mechanical stability | FGF-1 | [209, 210] |
Weaving | ||||
Nerve regenerattion | Biodegradable glass fabric | Mechanical stability | – | [211] |
Vascular graft | Woven tubes (luminal Ø 4 mm), with double-layered PGA (core)/PLLA (sheath) fibers + collagen microsponges | Mechanical stability; 3D porous environment |
– | [147, 164] |
Fascia replacement/hernia repair | Handwoven meshes from native dragline silk of Nephila spp. | Mechanical stability | – | [59] |
Tendon/Ligament repair | Layered PLLA fabrics; side A: smooth surface, side B: pile-finished surface | Mechanical stability; Control of cell migration/adhesion by adjusted surface structures |
– | [165] |
Woven PLA pad | Mechanical stability | – | [212] | |
Woven PLA (commercially available material) | Mechanical stability; Host tissue deposition | – | [166] | |
Braiding | ||||
Nerve regeneration | PGA tube + collagen sponge | Mechanical stability | Clinical studies | [179–181, 176] |
Braid of PLLA and PGA yarns (1:1) + collagen coating | Mechanical stability; PLLA for prolonged reinforcement |
– | [50] | |
Microbraided PLGA (10:90) tubes | Mechanical stability | – | [213] | |
Tendon/ligament repair | Lyophilized human fascia reinforced by braided PLLA/PGA fibers | Mechanical stability | – | [171, 172] |
PLLA braid + gelatin hydrogel + collagen membrane | Mechanical stability | bFGF | [146] | |
PLLA 3D square braid | Mechanical stability; Tissue ingrowth |
– | [173] | |
Non-woven | ||||
Nerve regeneration | poly[(R)-3-hydroxybutyrate] (PHB) non-woven | Mechanical stability | Clinical study | [196] |
Oriented silk-fibroin filaments | Mechanical stability; Aligned fibers for cell guidance |
– | [195] | |
Cartilage repair | PGA felt + hyaluronic acid/hyaluronan | Mechanical stability; Porous environment |
Allogeneic/autologous serum | [144, 145] |
Tendon/ligament repair | PGA sheet | Mechanial stability; Tissue ingrowth |
– | [193] |
Chitin sheet | Mechanial stability; Tissue ingrowth |
– | [194] |