Table 2.
Bonferonni Corrected P Values From Wald Tests of CDPR Contrasts at Each Time Using Estimates From ZIP Growth-Curve Model Predicting DAYS
| Smoking frequency (Poisson) | Smoking discontinuation (Logistic) | |||||
|---|---|---|---|---|---|---|
| Years since BL | Intermediate vs. Normal | Intermediate vs. Slow | Normal vs. Slow | Intermediate vs. Normal | Intermediate vs. Slow | Normal vs. Slow |
| 0 | 2.6E−04 | 1.8E−02 | 8.0E−01 | 1.1E−01 | 7.6E−04 | 8.3E−03 |
| 0.5 | 6.5E−04 | 1.1E−02 | 9.0E−01 | 1.3E−01 | 1.1E−03 | 9.3E−03 |
| 1.25 | 3.7E−03 | 5.4E−03 | 4.0E−01 | 2.2E−01 | 4.1E−03 | 1.6E−02 |
| 2 | 3.1E−02 | 2.5E−03 | 8.5E−02 | 4.7E−01 | 3.9E−02 | 6.2E−02 |
| 2.75 | 2.6E−01 | 1.5E−03 | 6.2E−03 | 9.7E−01 | 3.9E−01 | 3.2E−01 |
| 4 | 3.7E−01 | 2.8E−03 | 2.2E−05 | 3.7E−01 | 3.8E−01 | 7.8E−01 |
| 5 | 2.5E−02 | 1.2E−02 | 1.1E−06 | 2.0E−01 | 1.0E−01 | 3.9E−01 |
| 6 | 1.8E−03 | 4.8E−02 | 5.1E−07 | 1.4E−01 | 3.9E−02 | 2.3E−01 |
BL = baseline; CDPR = CYP2A6 diplotype predicted rate; ZIP = zero-inflated Poisson. A bold P value indicates a significant difference between CDPR categories at the .017-level. Since all CPDR contrasts were tested, a Bonferonni correction was applied (P value = .05/3 = .017). For each test the degrees of freedom equal one. See Supplementary Table S-3 for the parameter estimates, SEs, and P values for the ZIP growth-curve model predicting DAYS.