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Main determinants of cancer stem cell radioresistance
| Molecular determinants of radioresistance | Mechanism |
| Intrinsic determinants | Enhanced DNA repair capability |
| Protection from oxidative DNA damage | |
| Activation of the cell survival pathways | |
| (PI3K/Akt, WNT/β-catenin, notch) | |
| Expression of drug efflux pumps | |
| Extrinsic determinants | Hypoxic environment |
