Table 1.

The different genotype distribution of BDKRB-58T/C gene polymorphism for cases and controls

			Cases						Controls
Study	Year	Country	Distribution of genotype			Allele frequency		HWE	Distribution of genotype			Allele frequency		HWE	NOS score
								P-value						P-value
			TT	CT	CC	T	C		TT	CT	CC	T	C
Mukae S	1999	Japan	13	59	28	85	115	0.04	25	57	18	107	93	0.15	5
Gainer JV	2000	American	2	34	41	83	116	0.10	17	58	45	92	148	0.81	6
Aoki S	2001	Japan	19	88	43	126	174	0.01	38	84	28	160	140	0.13	5
Wang B	2001	China	15	74	31	104	136	0.01	24	57	17	105	91	0.09	5
Fu Y	2004	Japan	70	139	66	279	271	0.85	116	227	98	459	423	0.51	5
Cui J-1	2005	A-C	27	55	37	109	129	0.45	16	47	27	79	101	0.56	5
Cui J-2	2005	G-C	25	46	25	96	96	0.68	17	43	32	77	107	0.70	5
Cui J-3	2005	A-A	10	44	59	64	162	0.66	20	32	43	72	118	0.01	5
Cui J	2005	American	62	145	121	269	387	0.12	53	122	102	228	326	0.13	5
Milan A	2005	Italy	21	59	49	101	157	0.65	15	52	28	82	108	0.26	6
Dong HY	2006	China	15	47	35	78	116	0.91	24	51	11	98	74	0.05	6
Li NF	2008	China	102	199	53	403	305	0.06	62	106	48	230	202	0.83	6
Hang LW	2009	China	10	50	35	70	120	0.20	36	85	36	157	157	0.30	5
Bhupatiraju C	2011	India	39	101	74	179	249	0.66	53	122	74	228	270	0.84	5
Zou L	2011	China	30	49	24	109	97	0.65	25	48	30	98	108	0.50	5
Song J	2012	China	96	157	74	349	305	0.52	60	88	54	216	188	0.07	5

HWE: Hardy-Weinberg expectations, NOS: Newcastle-Ottawa Scale, A-C: American Caucasian, G-C: Greek Caucasian, A-A: African American.