Table 2.
Study | Type of study | Interventions (control group) | Interventions (experimental group) | Outcomes |
---|---|---|---|---|
Huang RL [9] (2014) | RCT | routine therapy (refered to 2008 SSCa guidelines) | routine therapy; Sini Decoction (ripe aconite root, dried ginger, honey-fried licorice root) | ACTH stimulating test; 28-day mortality; APACHE II score; 3-day shock recovery rate |
Shao M [10] (2011) | RCT | routine therapy (refered to 2004 SSCa guidelines, bundle theraphy) | routine therapy; Xuebijing injection (extractive of safflower, red peony root, rhizoma chuanxiong, salvia, angelica) | Expression rate of Th17 and CD4+ CD25+Treg; 28-day mortality; ICU stay; APACHE II score; |
Su YL [11] (2008) | RCT | routine therapy (refered to 2004 SSCa guidelines) | routine therapy; Qishen huoxue granule (astragalus membranaceus, salvia miltiorrhiza, flos carthami, angelica sinensis, chuanxiong, etc.) | 28-day mortality; ICU stay; Marshall score; APACHE II score; Serum inflammatory factors concentration |
Wang B [12] (2011) | RCT | routine therapyb | routine therapy; Modified Liang-Ge San (fructus forsythiae, scutellaria baicalensis, gardenia, lophatherum gracile, rheum officinale, mint, mirabilite, liquorice, radix scrophulariae, salvia miltiorrhiza, radix ophiopogonis, American ginseng) | Platelet parameters/activation; platelet TLR4 expression; intensity of inflammatory response; rate of bleeding; 28-day mortality; ICU stay; APACHE II score; TNF-α concentration |
Zhang CH [13] (2011) | RCT | routine therapyb | routine therapy; Hengyan medicinal recipe (bombyx batryticatus, periostracum cicada, turmeric, rheum officinale, astragalus membranaceus, radix ophiopogonis, red ginseng, cortex moutan, peach seed, flos carthami, etc.) | Number of bowel movement; levels of CD3+, CD4+, CD8+ T cell; APACHE II score; Serum inflammatory factors concentration |
Wang CX [14] (2011) | RCT | routine therapy (fluid resuscitation) | routine therapy; Modified Qianyang Pellet (fructus amomi, monkshood, tortoise plastron, rhizoma zingiberis, ephedra, honey-fried licorice root) | Extravascular lung wate parametersr; oxygenation index; 28-day mortality; |
Jiang RL [15] (2009) | RCT | routine therapy (refered to 2004 SSCa guidelines) | routine therapy; Shenfu injection (extractive of red ginseng and black Fupian) | DO2, VO2, ERO2, lactate clearance rate; 28-day mortality |
Qiu ZL [16] (2012) | RCT | routine therapy (refered to 2008 SSCa guidelines) | routine therapy; Shenfu injection (red ginseng, extractive of black Fupian) | 28-day mortality; Marshall score; APACHE II score; Serum inflammatory factors concentration |
Zhang SL [17] (2010) | RCT | routine therapyb | routine therapy; Fufang qingxia Decoction (rheum officinale, magnolia obavata, immature bitter orange, mirabilite, fructus forsythiae, dandelion, double blossom, gardenia, Cortex Moutan) | TNF-αconcentration; expression of TNF-α mRNA |
Gao ZL [18] (2012) | RCT | routine therapy (anti-infection, nutrition support, glucose control with insulin pump) | routine therapy; Shenmai injection (extractive of red ginseng and ophiopogon), sulfotanshinone sodium injection (extractive of Salviae Miltiorrhizae) | serum levels of CRP, TNF-α, IL-1, and IL-6; the HLA-DR expression of the peripheral monocytes; 28-day mortality; APACHE II score |
SSC: Surviving Sepsis Campaign;
no description about routine therapy in the study.