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. 2015 Nov 15;8(11):20024–20034.

Table 2.

Characteristics of included RCTs (part B)

Study Type of study Interventions (control group) Interventions (experimental group) Outcomes
Huang RL [9] (2014) RCT routine therapy (refered to 2008 SSCa guidelines) routine therapy; Sini Decoction (ripe aconite root, dried ginger, honey-fried licorice root) ACTH stimulating test; 28-day mortality; APACHE II score; 3-day shock recovery rate
Shao M [10] (2011) RCT routine therapy (refered to 2004 SSCa guidelines, bundle theraphy) routine therapy; Xuebijing injection (extractive of safflower, red peony root, rhizoma chuanxiong, salvia, angelica) Expression rate of Th17 and CD4+ CD25+Treg; 28-day mortality; ICU stay; APACHE II score;
Su YL [11] (2008) RCT routine therapy (refered to 2004 SSCa guidelines) routine therapy; Qishen huoxue granule (astragalus membranaceus, salvia miltiorrhiza, flos carthami, angelica sinensis, chuanxiong, etc.) 28-day mortality; ICU stay; Marshall score; APACHE II score; Serum inflammatory factors concentration
Wang B [12] (2011) RCT routine therapyb routine therapy; Modified Liang-Ge San (fructus forsythiae, scutellaria baicalensis, gardenia, lophatherum gracile, rheum officinale, mint, mirabilite, liquorice, radix scrophulariae, salvia miltiorrhiza, radix ophiopogonis, American ginseng) Platelet parameters/activation; platelet TLR4 expression; intensity of inflammatory response; rate of bleeding; 28-day mortality; ICU stay; APACHE II score; TNF-α concentration
Zhang CH [13] (2011) RCT routine therapyb routine therapy; Hengyan medicinal recipe (bombyx batryticatus, periostracum cicada, turmeric, rheum officinale, astragalus membranaceus, radix ophiopogonis, red ginseng, cortex moutan, peach seed, flos carthami, etc.) Number of bowel movement; levels of CD3+, CD4+, CD8+ T cell; APACHE II score; Serum inflammatory factors concentration
Wang CX [14] (2011) RCT routine therapy (fluid resuscitation) routine therapy; Modified Qianyang Pellet (fructus amomi, monkshood, tortoise plastron, rhizoma zingiberis, ephedra, honey-fried licorice root) Extravascular lung wate parametersr; oxygenation index; 28-day mortality;
Jiang RL [15] (2009) RCT routine therapy (refered to 2004 SSCa guidelines) routine therapy; Shenfu injection (extractive of red ginseng and black Fupian) DO2, VO2, ERO2, lactate clearance rate; 28-day mortality
Qiu ZL [16] (2012) RCT routine therapy (refered to 2008 SSCa guidelines) routine therapy; Shenfu injection (red ginseng, extractive of black Fupian) 28-day mortality; Marshall score; APACHE II score; Serum inflammatory factors concentration
Zhang SL [17] (2010) RCT routine therapyb routine therapy; Fufang qingxia Decoction (rheum officinale, magnolia obavata, immature bitter orange, mirabilite, fructus forsythiae, dandelion, double blossom, gardenia, Cortex Moutan)     TNF-αconcentration; expression of TNF-α mRNA
Gao ZL [18] (2012) RCT routine therapy (anti-infection, nutrition support, glucose control with insulin pump) routine therapy; Shenmai injection (extractive of red ginseng and ophiopogon), sulfotanshinone sodium injection (extractive of Salviae Miltiorrhizae) serum levels of CRP, TNF-α, IL-1, and IL-6; the HLA-DR expression of the peripheral monocytes; 28-day mortality; APACHE II score
a

SSC: Surviving Sepsis Campaign;

b

no description about routine therapy in the study.